Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
Identifieur interne : 008819 ( Main/Exploration ); précédent : 008818; suivant : 008820Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
Auteurs : Lone Gothard [Royaume-Uni] ; Paul Cornes ; Judith Earl ; Emma Hall ; Julie Maclaren ; Peter Mortimer (dermatologue) [Royaume-Uni] ; John Peacock ; Clare Peckitt ; Mary Woods ; John YarnoldSource :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [ 0167-8140 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association de médicaments, Association thérapeutique, Dosimétrie en radiothérapie, Femelle, Fibrose (anatomopathologie), Fibrose (traitement médicamenteux), Fibrose (étiologie), Humains, Intervalles de confiance, Lymphoedème (traitement médicamenteux), Lymphoedème (étiologie), Maladie chronique, Mastectomie (), Mastectomie (effets indésirables), Méthode en double aveugle, Pentoxifylline (usage thérapeutique), Probabilité, Qualité de vie, Radiothérapie adjuvante (), Radiothérapie adjuvante (effets indésirables), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Valeurs de référence, Vitamine E (usage thérapeutique), Études de suivi, Évaluation des risques.
- MESH :
- anatomopathologie : Fibrose, Tumeurs du sein.
- effets indésirables : Mastectomie, Radiothérapie adjuvante.
- traitement médicamenteux : Fibrose, Lymphoedème.
- usage thérapeutique : Pentoxifylline, Vitamine E.
- étiologie : Fibrose, Lymphoedème.
- Adulte, Adulte d'âge moyen, Association de médicaments, Association thérapeutique, Dosimétrie en radiothérapie, Femelle, Humains, Intervalles de confiance, Maladie chronique, Mastectomie, Méthode en double aveugle, Probabilité, Qualité de vie, Radiothérapie adjuvante, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, Valeurs de référence, Études de suivi, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Breast Neoplasms (pathology), Breast Neoplasms (therapy), Chronic Disease, Combined Modality Therapy, Confidence Intervals, Double-Blind Method, Drug Therapy, Combination, Female, Fibrosis (drug therapy), Fibrosis (etiology), Fibrosis (pathology), Follow-Up Studies, Humans, Lymphedema (drug therapy), Lymphedema (etiology), Mastectomy (adverse effects), Mastectomy (methods), Middle Aged, Pentoxifylline (therapeutic use), Probability, Quality of Life, Radiotherapy Dosage, Radiotherapy, Adjuvant (adverse effects), Radiotherapy, Adjuvant (methods), Reference Values, Risk Assessment, Treatment Outcome, Vitamin E (therapeutic use).
- MESH :
- chemical , therapeutic use : Pentoxifylline, Vitamin E.
- adverse effects : Mastectomy, Radiotherapy, Adjuvant.
- drug therapy : Fibrosis, Lymphedema.
- etiology : Fibrosis, Lymphedema.
- methods : Mastectomy, Radiotherapy, Adjuvant.
- pathology : Breast Neoplasms, Fibrosis.
- therapy : Breast Neoplasms.
- Adult, Aged, Aged, 80 and over, Chronic Disease, Combined Modality Therapy, Confidence Intervals, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Middle Aged, Probability, Quality of Life, Radiotherapy Dosage, Reference Values, Risk Assessment, Treatment Outcome.
Abstract
Treatment-induced arm lymphoedema is a common and distressing complication of curative surgery and radiotherapy for early breast cancer. A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials. Arm lymphoedema after lymphatic radiotherapy and surgery has been used in the present study as a clinical system for testing these drugs in a double-blind placebo-controlled randomised phase II trial.
DOI: 10.1016/j.radonc.2004.09.013
PubMed: 15542159
Affiliations:
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xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (therapy)</term><term>Chronic Disease</term><term>Combined Modality Therapy</term><term>Confidence Intervals</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Fibrosis (drug therapy)</term><term>Fibrosis (etiology)</term><term>Fibrosis (pathology)</term><term>Follow-Up Studies</term><term>Humans</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Mastectomy (adverse effects)</term><term>Mastectomy (methods)</term><term>Middle Aged</term><term>Pentoxifylline (therapeutic use)</term><term>Probability</term><term>Quality of Life</term><term>Radiotherapy Dosage</term><term>Radiotherapy, Adjuvant (adverse effects)</term><term>Radiotherapy, Adjuvant (methods)</term><term>Reference Values</term><term>Risk Assessment</term><term>Treatment Outcome</term><term>Vitamin E (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Femelle</term><term>Fibrose (anatomopathologie)</term><term>Fibrose (traitement médicamenteux)</term><term>Fibrose (étiologie)</term><term>Humains</term><term>Intervalles de confiance</term><term>Lymphoedème (traitement médicamenteux)</term><term>Lymphoedème (étiologie)</term><term>Maladie chronique</term><term>Mastectomie ()</term><term>Mastectomie (effets indésirables)</term><term>Méthode en double aveugle</term><term>Pentoxifylline (usage thérapeutique)</term><term>Probabilité</term><term>Qualité de vie</term><term>Radiothérapie adjuvante ()</term><term>Radiothérapie adjuvante (effets indésirables)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Valeurs de référence</term><term>Vitamine E (usage thérapeutique)</term><term>Études de suivi</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Pentoxifylline</term><term>Vitamin E</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term><term>Radiotherapy, Adjuvant</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fibrose</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Fibrosis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term><term>Radiothérapie adjuvante</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fibrosis</term><term>Lymphedema</term></keywords><keywords 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Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Probability</term><term>Quality of Life</term><term>Radiotherapy Dosage</term><term>Reference Values</term><term>Risk Assessment</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Femelle</term><term>Humains</term><term>Intervalles de confiance</term><term>Maladie chronique</term><term>Mastectomie</term><term>Méthode en double aveugle</term><term>Probabilité</term><term>Qualité de vie</term><term>Radiothérapie adjuvante</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein</term><term>Valeurs de référence</term><term>Études de suivi</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment-induced arm lymphoedema is a common and distressing complication of curative surgery and radiotherapy for early breast cancer. A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials. Arm lymphoedema after lymphatic radiotherapy and surgery has been used in the present study as a clinical system for testing these drugs in a double-blind placebo-controlled randomised phase II trial.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><noCountry><name sortKey="Cornes, Paul" sort="Cornes, Paul" uniqKey="Cornes P" first="Paul" last="Cornes">Paul Cornes</name><name sortKey="Earl, Judith" sort="Earl, Judith" uniqKey="Earl J" first="Judith" last="Earl">Judith Earl</name><name sortKey="Hall, Emma" sort="Hall, Emma" uniqKey="Hall E" first="Emma" last="Hall">Emma Hall</name><name sortKey="Maclaren, Julie" sort="Maclaren, Julie" uniqKey="Maclaren J" first="Julie" last="Maclaren">Julie Maclaren</name><name sortKey="Peacock, John" sort="Peacock, John" uniqKey="Peacock J" first="John" last="Peacock">John Peacock</name><name sortKey="Peckitt, Clare" sort="Peckitt, Clare" uniqKey="Peckitt C" first="Clare" last="Peckitt">Clare Peckitt</name><name sortKey="Woods, Mary" sort="Woods, Mary" uniqKey="Woods M" first="Mary" last="Woods">Mary Woods</name><name sortKey="Yarnold, John" sort="Yarnold, John" uniqKey="Yarnold J" first="John" last="Yarnold">John Yarnold</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Gothard, Lone" sort="Gothard, Lone" uniqKey="Gothard L" first="Lone" last="Gothard">Lone Gothard</name></noRegion><name sortKey="Mortimer, Peter" sort="Mortimer, Peter" uniqKey="Mortimer P" first="Peter" last="Mortimer">Peter Mortimer (dermatologue)</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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